Acarbose for the Treatment of Diabetes Mellitus [Paperback]

New principles for the treatment of diabetes are described in this volume. Experts present experimental and clinical data on treatment with acarbose, an alpha-glucosidase inhibitor that delays absorption of fast carbohydrates. Toxicologic, pharmacologic and metabolic effects of acarbose are discussed. A concluding section on the future aspects of alpha-glucosidase inhibition offers a fair assessment of therapeutic possibilities.New principles for the treatment of diabetes are described in this volume. Experts present experimental and clinical data on treatment with acarbose, an alpha-glucosidase inhibitor that delays absorption of fast carbohydrates. Toxicologic, pharmacologic and metabolic effects of acarbose are discussed. A concluding section on the future aspects of alpha-glucosidase inhibition offers a fair assessment of therapeutic possibilities.Experimental Data on Acarbose I.- Toxicology of Acarbose, with Special Reference to Long-Term Carcinogenicity Studies.- Discussion.- The Disposition and Pharmacokinetics of Acarbose in Man.- Discussion.- Experimental Data on Acarbose II.- The Pharmacological Rationale of Diabetes Mellitus Therapy with Acarbose.- Discussion.- Pharmacodynamics of Acarbose: Clinical Investigations.- Discussion.- Posters.- Comparative Effects of Acarbose on Glycemia, Weight Gain, and Serum Lipids in Adult Male and Female Diabetic Wistar Fatty Rats.- Effects of Low-Dose Acarbose on Glycemia, Adiposity, and Cholesterolemia in Obese and Obese Non-Insulin-Dependent Diabetic Corpulant Rats.- A Preclinical Study on the Effects of Acarbose on Mice Rendered Obese with Gold Thioglucose.- Enhancement of Insulin Binding and Glucose Transport by Acarbose in Adipocytes of Zucker Rats.- Treatment of Streptozotocin-Diabetic Rats with Acarbose: Influence on Metabolism and Heart Function.- Effects of Acarbose on Cardiac and Hepatic Metabolism in Diabetic Rats.- Effects of Acarbose on Experimental Diabetic Nephropathy, Metabolic Control, and Intestinal Glycl#˜