Acute Phase Proteins in the Acute Phase Response [Paperback]

1 Interleukin-1 in the Acute Phase Response.- The Acute Phase Response.- Structure of IL-1.- Synthesis and Regulation of IL-1.- IL-1 Receptor.- Pleotropic Actions of IL-1.- IL-1 and Acute Phase Reactions.- Fever.- Leukocytosis.- Acute Phase Proteins.- IL-1 and Other Cytokines.- Synergy of Action.- Induction of Other Cytokines by IL-1.- IL-1 and Corticosteroid.- In Vivo Action of IL-1.- Summary.- 2 Regulation of Human SAA Gene Expression by Cytokines.- In Vitro Expression of Human SAA.- Cis-acting Sequences Responsible for PMA Induction of SAA.- Cytokine Control of SAA Expression.- 3 Transcriptional Regulation of Acute Phase Response Genes with Emphasis on the Human C-reactive Protein Gene.- The Physiological Role of the Acute Phase Response.- Systems for the Study of the Acute Phase Response.- Monokines Responsible for the Modulation of Liver-specific Gene Expression.- Transcriptional Regulation  the Mechanism.- Liver-specific Promoters and Enhancers.- Promoters Induced During the Acute Phase.- Conclusions and Perspectives.- 4 Organization, Structure and Expression of Pentraxin Genes.- The Structure of Pentraxin Proteins.- The Structure of Pentraxin Genes.- Heat Shock Elements.- The Purine-Pyrimidine Repeat Region and Oligo-A Stretch in the CRP Intron.- The 3? Untranslated Region.- Elements Responding to Cytokines.- Genetics.- 5 ApoSSA: Structure, Tissue Expression and Possible Functions.- Background.- SAA is an Apolipoprotein.- Where are SAAs Made and Where do They go?.- Patterns of Cell and Tissue Expression of SAA mRNAs in Mice.- Rats Have SAA-related Genes.- Summary.- 6 Regulation of Biosynthesis and Secretion of Human C-reactive Protein and Serum Amyloid A.- Regulation of Biosynthesis.- Role of Cytokines.- Role of Cofactors: Signal Transduction.- Heterogeneity in the Acute Phase Response.- Regulation of CRP Secretion.- Dynamics of CRP Secretion by Rabbit.- Hepatocytes.- Subcellular Localization of the Intracellular Pool of CRP.- CRP is Specifically Retained Wil#˜