Advances in Immunology [Hardcover]

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

• Contributions from leading authorities and industry experts
• Informs and updates on all the latest developments in the field

1. Modeling a Complex Disease: Multiple Sclerosis

Florian C. Kurschus, Simone W?rtge and Ari Waisman

2. The IgH Locus 3' Regulatory Region: Pulling the Strings from Behind

Eric Pinaud, Marie Marquet, R?mi Fiancette, Sophie P?ron, Christelle Vincent-Fabert, Yves Denizot and Michel Cogn?

3. Transcriptional and Epigenetic Regulation of CD4/CD8 Lineage Choice

Ichiro Taniuchi and Wilfried Ellmeier

4. Autoinflammation by Endogenous DNA

Shigekazu Nagata and Kohki Kawane

5. AID targeting in Antibody Diversity

Rushad Pavri and Michel C. Nussenzweig

Cutting-edge reviews in immunology

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian l.