Antidepressants: New Pharmacological Strategies [Paperback]

In this book, leading-edge investigators offer effective strategies to improve current antidepressive therapies and suggest molecular, biological, and genetic approaches that will lead to the development of novel antidepressants. The contributors' critical reviews and commentaries illuminate our understanding of the mechanism(s) responsible for antidepressant action. The book's goal is to move beyond current biogenic amine-based concepts and therapies to the development of new and improved antidepressants that are more effective and have a more rapid onset than current.In this book, leading-edge investigators offer effective strategies to improve current antidepressive therapies and suggest molecular, biological, and genetic approaches that will lead to the development of novel antidepressants. The contributors' critical reviews and commentaries illuminate our understanding of the mechanism(s) responsible for antidepressant action. The book's goal is to move beyond current biogenic amine-based concepts and therapies to the development of new and improved antidepressants that are more effective and have a more rapid onset than current.Strategies to Optimize the Antidepressant Action of Selective Serotonin Reuptake Inhibitors, Luz Romero, Josep M. Casanovas, Ildefons Herv?s, Roser Cort?s, and Francesc Artigas. Antidepressant Properties of Specific Serotonin-Noradrenaline Reuptake Inhibitors, Michael Briley and Chantal Moret. 5-HT Moduline: Novel Therapeutic Strategy for Antidepressant Action, Gilles Fillion, Laure Seguin, Olivier Massot, Jean-Claude Rousselle, Marie-Paule Fillion, Isabelle Clo?z-Tayarani, Brigitte Grimaldi, Jean-Christophe Seznec, and Nicole Prudhomme. Reversible Inhibitors of Monoamine Oxidase A (RIMAs): Where Can We Go from Here? Vivette Glover. Calcium Channel Antagonists in Mood Disorders, Olgierd Pucilowski. Functional NMDA Antagonists: A New Class of Antidepressant Agents, Ramon Trullas. Is an Adaptation of NMDA Receptors an Obligatory Step in Als4