The Art of Drug Synthesis [Hardcover]

The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis.

• Edited by prominent scientists working in drug discovery for Pfizer
• Meets the needs of a growing community of researchers in pharmaceutical R&D
• Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students
• An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

Foreword xi

Preface xiii

Contributors xv

1 THE ROLE OF MEDICINAL CHEMISTRY IN DRUG DISCOVERY 1
John A. Lowe, III

1.1 Introduction 1

1.2 Hurdles in the Drug Discovery Process 2

1.3 The Tools of Medicinal Chemistry 3

1.4 The Role of Synthetic Chemistry in Drug Discovery 6

2 PROCESS RESEARCH: HOW MUCH? HOW SOON? 11
Neal G. Anderson

2.1 Introduction 11

2.2 Considerations for Successful Scale-up to Tox Batches and Phase I Material 15

2.3 Considerations for Phase 2 Material and Beyond 16

2.4 Summary 26

I CANCER AND INFECTIOUS DISEASES

3 AROMATASE INHIBITORSl£3