Autoimmunity Experimental Aspects [Paperback]

Combining principles of contemporary immunology with applications to immunopathology, this up-to-date volume documents new developments in the understanding of the origin of autoimmune diseases. Emphasized are cellular and molecular approaches in both organ-specific and systemic autoimmunity. A comprehensive bibliography, numerous illustrations, and tables make it an invaluable source of information for immunologists, rheumatologists, pathologists, dermatologists, and nephrologists.Proceedings of the NATO Advanced Research Workshop on Fundamental and Experimental Aspects of Autoimmunity, held at Acquafredda di Maratea, Italy, May 22 - 26, 1993Combining principles of contemporary immunology with applications to immunopathology, this up-to-date volume documents new developments in the understanding of the origin of autoimmune diseases. Emphasized are cellular and molecular approaches in both organ-specific and systemic autoimmunity. A comprehensive bibliography, numerous illustrations, and tables make it an invaluable source of information for immunologists, rheumatologists, pathologists, dermatologists, and nephrologists.1. Thymic Selection and Peripheral T cell Tolerance.- Tolerance induction in mature peripheral T cells.- Transgenic mice carrying the rearranged T cell receptor of a diabetogenic T cell clone.- The maintenance and reestablishment of self tolerance: T cell receptor (TCR) peptide-specific regulatory T cells.- Prevention of gastric autoimmunity by transgenic expression of a proton pump subunit in the thymus.- 2. B-cell repertoire selection.- The anti-self B-cell repertoire.- In vivo suppression of IgG2ab production accomplished by CD4+8? Th1 cell clones specific for a ?2ab allopeptide determinant.- 3. Targets of the autoimmune response.- Expression cloning using antibodies from a patient with rheumatoid arthritis of an autoantigen homologous to the Drosophila splicing regulator, suppressor-of-white-apricot.- Use of synthetic peptides for the analysis ofl£‡