Biomarkers for Alzheimers Disease Drug Development [Hardcover]

This volume aims to build a new generation of experts with a broader understanding of key topics in the Alzheimers disease field. Chapters guide readers through innovative approaches to the discovery of novel biomarkers in cerebrospinal fluid, innovation in blood-based biomarkers, a comprehensive overview of magnetic resonance imaging and molecular imaging approaches and their value for developing drugs for Alzheimers disease, cutting-edge developments in neuropathology and their relevance for Alzheimers disease trials, novel genomic strategies for biomarker development, and related topics including neuropsychological testing and advanced analytical methods.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

?

Authoritative and cutting-edge, Biomarkers for Alzheimer's Disease Drug Development aims to ensure successful results in the further study of this vital field.?

PART I: The need for Alzheimers Disease Biomarkers

1. Epidemiology of Dementia: The Burden on Society, the Challenges for Research

Frank J. Wolters and M. Arfan Ikram

?

2. Population-based Approaches to Alzheimers Disease Prevention

Robert Perneczky

?

3. Systems Biology Methods for Alzheimers Disease Research towards Molecular Signatures, Subtypes and Stages and Precision Medicine. Application in Cohort Studies and Trials

Juan I. Castrillo, Simone Lista, Harald Hampel, and Craig W. Ritchie

?

?

PART II: InnovalE