Biophysical approaches to translational control of gene expression [Paperback]

This book provides a premier resource on understanding the ribosome's essential nature and how it interacts with other proteins and nucleic acids to control protein synthesis. As one of the central foundations in our understanding of the biology at the molecular level, this topic appeals to a wide audience, from bench researcher to clinician. ?With the advent of atomic scale structures, methods to visualize and separate individual molecules, and the computational power to model the complex interactions of over a million atoms at once, our understanding of how gene expression is controlled at the level of protein translation is now deeply ensconced in the biophysical realm.

1.?X-ray analysis of prokaryotic and eukaryotic ribosomes.?
Lasse B. Jenner, Adam Ben-Shem,? Natalia Demeshkina, Marat Yusupov*, Gulnara Yusupova.??

2.?A passage through the ribosome by Cryo-EM.?
Partha P. Datta and Ananya Chatterjee

3.?Molecular dynamics simulations of the ribosome.
Karissa Y. Sanbonmatsu, Scott C. Blanchard and Paul C. Whitford.

4.?Structural analyses of the ribosome by chemical modification methods.
Jonathan A. Leshin, Arturas Meskauskas, and Jonathan D. Dinman.

5.?Methods for studying the interactions of translation factors with the ribosome.?
Assen Marintchev?

6.?Riboproteomic approaches to understanding IRES elements.
Encarnacion Martinez-Salas, David Pi?eiro and Noemi Fernandez.????

7.?Rapid kinetic analysis of protein synthesis.?
Marina V. Rodnina and Wolfgang Wintermeyer.??

8.?Investigating RNAs Involvedl£ª