Cell Signaling in Vascular Inflammation [Hardcover]

A comprehensive survey by leading basic and clinical researchers of the signal transduction mechanisms responsible for lung inflammation, including vascular hyperpermeability, white cell accumulation, and vascular remodeling. The authors cut across disciplines to bring together a broad-based presentation of inflammatory challenge, both in the initial phases of the inflammatory response, as well as in the more prolonged phase of genomic involvement. The book illuminates not only the processes of lung inflammation, but also the potential for developing new therapeutic strategies to combat inflammatory lung disease.A comprehensive survey by leading basic and clinical researchers of the signal transduction mechanisms responsible for lung inflammation, including vascular hyperpermeability, white cell accumulation, and vascular remodeling. The authors cut across disciplines to bring together a broad-based presentation of inflammatory challenge, both in the initial phases of the inflammatory response, as well as in the more prolonged phase of genomic involvement. The book illuminates not only the processes of lung inflammation, but also the potential for developing new therapeutic strategies to combat inflammatory lung disease.Heme Oxygenase-1 and Carbon Monoxide in Vascular RegulationStefan W. Ryter and Augustine M. K. ChoiTumor Necrosis Factor-a/Receptor Signaling Through the Akt KinaseOsman Nidai Ozes, Hakan Akca, Jason A. Gustin, Lindsey D. Mayo, Roxana Pincheira, Chandrashekhar K. Korgaonkar, and David B. DonnerProtein Modifications by Nitric Oxide and Reactive Nitrogen SpeciesHarry IschiropoulosRedox Signaling in Hypoxic Pulmonary VasoconstrictionE. Kenneth Weir, Zhigang Hong, Anthony Varghese, Daniel P. Nelson, and Andrea OlschewskicGMP-Dependent Protein Kinase in Regulation of the Perinatal Pulmonary CirculationUsha Raj, Yuansheng Gao, Srinivas Dhanakoti, and Fred SanderGlutamate Receptor Activation in the Pathogenesis of Acute Leg InjurySami I. SaidCarboxyl MethyllóT