Cellular Mechanotransduction Diverse Perspectives from Molecules to Tissues [Paperback]

This book focuses on the process of stress sensing and transducing mechanical force into biochemical signals.Living tissues sense mechanical stress and respond by tissue remodeling and by sending biochemical signals that produce a sequence of biological responses. This book focuses on the process of stress sensing and transducing mechanical force into biochemical signals. It helps define mechanomics, which describes the mechanical state of a biological system.Living tissues sense mechanical stress and respond by tissue remodeling and by sending biochemical signals that produce a sequence of biological responses. This book focuses on the process of stress sensing and transducing mechanical force into biochemical signals. It helps define mechanomics, which describes the mechanical state of a biological system.Mechanotransduction is the term for the ability, first described by 19th-century anatomist Julius Wolff, of living tissues to sense mechanical stress and respond by tissue remodeling. More recently, the scope of mechanotransduction has been expanded to include the sensation of stress, its translation into a biochemical signal, and the sequence of biological responses it produces. This book looks at mechanotransduction in a more restricted sense, focusing on the process of stress sensing and transducing a mechanical force into a cascade of biochemical signals. This stress has become increasingly recognized as one of the primary and essential factors controlling biological functions, ultimately affecting the function of the cells, tissues, and organs. A primary goal of this broad book is also to help define the new field of mechanomics, which attempts to describe the complete mechanical state of a biological system.1. Introduction Roger D. Kamm and Mohammad R. K. Mofrad; 2. Endothelial mechanotransduction Peter F. Davies and Brian P. Helmke; 3. Role of the plasma membrane in endothelial cell mechanosensation of shear stress Peter J. Butler and Shu Chien; 4. Ml³-