The Chemistry of <i>C</i>-Glycosides [Paperback]

In recent years C-glycoside chemistry has been one of the main topics in carbohydrate chemistry, not only because of the synthetic challenges posed, but also because C-glycosides have the potential to serve as carbohydrate analogues resistant to metabolic processes. Consequently, this class of compounds is currently receiving much interest as a potential source of therapeutic agents for clinical use. This book provides a broad coverage of the various synthetic methods available for the preparation of C-glycosides, and illustrates the interesting breadth of connections between carbohydrate chemistry and modern general synthetic organic chemistry by including topics such as transition-metal catalysis, radical chemistry, cycloaddition and rearrangement processes. In addition, in the final chapter of the book, the syntheses of C-di and trisaccharides reported through 1994 are reviewed. This well organised account of the synthetic chemistry in this field will prove to be very valuable to a wide range of researchers and advanced students, both as an introduction to the topic and for reference.Introduction. Electrophilic Substitutions. Nucleophilic Sugar Substitutions. Transition Metal Mediated C-Glycosidations. Anomeric Radicals. Rearrangements and Cycloadditions. Sugar Ring Formations. Syntheses of C-Di and Trisaccharides. Index.This is a monumental work that provides essentially comprehensive coverage of C-gylcosides. This book shows various synthetic methods available for the preparation of C-glycosides, and illustrates the interesting breadth of connections between carbohydrate chemistry and modern general synthetic organic chemistry.... It should become an important companion for both graduate students and senior researchers in the field.
Heterocycles
Geert-Jan Boons
The book discusses the chemistry of C-glycosides in eight chapters.... The followlóZ