The Chemistry of the Morita-Baylis-Hillman Reaction RSC [Hardcover]

The carbon-carbon bond formation and the functional group transformations are the most fundamental reactions for the construction of a molecular framework and are at the forefront of research in organic chemistry. This unique book covers the Morita-Baylis-Hillman-type reactions which possess the two most important requirements in modern organic chemistry - atom economy and generation of multi-functional groups. The book focuses on the summary of Morita-Baylis-Hillman (MBH) reaction, aza-MBH reaction and asymmetric MBH/aza-MBH reaction as well as the synthetic applications. New research in MBH/aza-MBH reaction including mechanistic investigation are also included. This book serves as a reference book for graduate students as well as chemists at all levels in both academic and industrial laboratories.Carbon-carbon bond formations and functional group transformations are the most fundamental reactions for the construction of molecular frameworks and are at the forefront of organic chemistry research. The Morita-Baylis-Hillman (MBH) type reactions possess the two most important requirements - atom economy and generation of multi-functional groups. The last decade has seen exponential growth of the MBH reaction and its applications. In fact, it is already one of the most powerful carbon-carbon bond-forming methods widely used in organic synthesis. Since the 1990s, more and more research groups have initiated work on different aspects of the MBH reaction. These have focused on the scope of the substrates, novel catalysts (especially chiral catalysts), reaction mechanisms, and synthetic applications. Consequently, there is now a need for a reference detailing the chemistry of this important reaction. This unique book summarizes the MBH reaction, aza-MBH reaction and asymmetric MBH/aza-MBH reaction including the latest research and mechanistic investigations. It provides a complete overview of MBH-type reactions aimed at synthetic organic chemists of all levels within acadel“,