Comparative Genomics: Volume 2 [Paperback]

This volume provides a collection of robust protocols for molecular biologists studying comparative genomics. Each chapter includes detailed instructions for using a particular tool or method and an introduction to the theory behind the technique. Given the tremendous increase in available biosequence data over the past ten years, this volume is timely, comprehensive, and novel.

Comparative Genomics, Volume 2, provides a collection of robust protocols for molecular biologists beginning to use comparative genomic analysis tools in a variety of areas. Volume 2 contains the last three of seven sections. In the second volume, the fifth section describes a number of tools for comparative analysis of domain and gene families. These tools are particularly useful for predicting protein function as well as potential protein-protein interactions. In the sixth section, methods for comparing groups of genes and gene order are discussed, as are several tools for analyzing genome evolution. Finally, the seventh section deals with experimental comparative genomics. This section includes methods for comparing gene copy number across an entire genome, comparative genomic hybridization, SNP analysis, as well as genome-wide mapping and typing systems for bacterial genomes. Given the tremendous increase in available biosequence data over the past ten years, Comparative Genomics, Volume 1, is timely, comprehensive, and novel. A companion Volume 1 is also available from Humana Press.

Comparative Genomics-Volume IITable of ContentsSection V-Comparative Analysis of Domain and Protein Families1. Computational Prediction of Domain InteractionsPhilipp Pagel, Normann Strack, Matthias Oesterheld, Volker St?mpflen,and Dmitrij Frishman2. DomainTeam: Synteny of domains is a new approach in comparativegenomicsSophie Pasek3. Inference of gene function based on gene fusion events: the RosettaStone methodKarsten Suhre4. Pfam: A domain-centric method for analyzing prl!