Disruption of Protein-Protein Interfaces: In Search of New Inhibitors [Paperback]

Disruption of Protein-Protein Interfaces reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces. The authors detail experimental and computational tools to tackle the subject and highlight the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs. Consequently, in recent years great effort has been dedicated to unveiling the molecular details of protein-protein interfaces by structural techniques e.g. X-ray diffraction, NMR spectroscopy. This book, written and edited by leaders in the field, provides examples from the literature of successes and failures to develop drug-like molecules effective in interacting at protein-protein interfaces.This book examines the present and future of drug discovery at protein-protein interfaces. It details computational and experimental tools used in the field, and offers examples of drug-like molecules effective in interacting at protein-protein interfaces.Drug discovery by targeting protein-protein interactions.- Protein-Protein Interaction Inhibitors: case studies on small molecules and natural compounds.- Disrupting Protein-Protein Interfaces using GRID Molecular Interaction Fields.- NMR as a tool to target protein-protein interactions.- Protein-protein interactions in the solid state The troubles of crystallizing of protein- protein complexes.- Fluorescence observables and enzyme kinetics in the investigation of PPI modulation by small molecules Detection, mechanistic insight, functional consequences.

Stefano Mangani has been professor of general and inorganic chemistry at the University of Siena since 1994. His main field of research is bioinorganic chemistry and structural biology and he currently focuses on the role of metal ions in metalloenzyme catalysis and in metalloproteins, with particular emphasis on the chemistry occurring at the metalƒ]