Drug Delivery Systems in Cancer Therapy [Paperback]

Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.Part I: Pharmacological Considerations for Drug Delivery Systems in Cancer MedicineSystemically Administered DrugsReginald B. Ewesuedo and Mark J. RatainRegional Administration of Antineoplastic DrugsMaurie MarkmanTheoretical Analyses and Simulations of Anticancer Drug DeliveryArdith W. El-Kareh and Timothy W. SecombPart II: Technologies Available for Use in Cancer Drug Delivery SystemsBiopolymers for Parenteral Drug Delivery in Cancer TreatmentWolfgang FriessHydrogels in Cancer Drug Delivery SystemsSung-Joo Hwang, Namjin Baek, Haesun Park, and Kinam ParkMicroparticle Drug Delivery SystemsDuane T. Birnbaum and Lisa Brannon-PeppasPolyethylene Glycol Conjugation of Prl“Y