A detailed account of information regarding neural stem cells has been described in this profound book. Twenty years post the discovery of neural stem cells; the problem whether the central nervous system can be regarded as a regenerative tissue still exists. A broad analysis of neural stem and progenitor cells, their niches, and their progeny in brain neurogenic sites clearly reflects that creation of new neurons in the brain of adult mammals including humans is possible. On the contrary, several complications emerge with the interaction of stem cells with mature brain parenchyma, still impeding the formulation of efficient approaches with endogenous or exogenously-delivered neural stem cells. This book attempts to deal with these unresolved issues which hold great scope of research in coming future.