Free radicals, molecules with unpaired electrons, are highly reactive and play key roles in physiologic regulation and in many degenerative and pathologic processes, making them a fertile area of research. This book focuses on spin trapping, a sophisticated technique for the identification of free radicals in biological systems. The method is complex, and this book offers an in-depth guide to all of the critical aspects needed for its application to free radicals in biology. This includes advice on interpreting results, trouble-shooting, and experimental designs. The book looks at future directions in the field and will prove an invaluable resource for investigators working in the biology of free radicals, regardless of whether they are new or highly experienced in the applications of spin trapping.
1. In the Beginning 2. The Oxygen Paradox 3. Nitric Oxide: A Simple Molecule with Complex Biological Functions 4. Methods of Free Radical Detection 5. Spin Trapping Free Radicals: Historical Perspective 6. The Synthesis of Spin Traps 7. Electron Paramagnetic Resonance Spectroscopy: Principles and Practical Aspects 8. Kinetics of Spin Trapping Free Radicals 9. The Chemistry of Spin Traps and Spin Trapped Adducts 10. Spin Trapping Free Radicals in Biological Systems 11. The Pharmacological Activity of Spin Traps 12. Future Directions Notes Index
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