From Molecule to Men: Molecular Basis of Congenital Cardiovascular Disorders [Paperback]

From molecule to man: Medical research has indeed taken this direction, and major improvements of our understanding of the pathophysiology and epidemiology of disease have been achieved. The molecular basis of the congenital cardiovascular disorders has been extended from relatively few congenital malformations into everyday illnesses such as diabetes mellitus, hyperlipoproteinaemea, and arterial hypertension. The monogenic and, more difficult, polygenic basis for a vast majority of cardiovascular disorders are being defined more precisely from year to year. This book gives an overview of what has been achieved so far and defines the current position.From molecule to man: Medical research has indeed taken this direction, and major improvements of our understanding of the pathophysiology and epidemiology of disease have been achieved. The molecular basis of the congenital cardiovascular disorders has been extended from relatively few congenital malformations into everyday illnesses such as diabetes mellitus, hyperlipoproteinaemea, and arterial hypertension. The monogenic and, more difficult, polygenic basis for a vast majority of cardiovascular disorders are being defined more precisely from year to year. This book gives an overview of what has been achieved so far and defines the current position.Molecular Basis of Congenital Cardiovascular Disorders.- Genetics of dilated cardiomyopathy.- Registry of families with inherited dilated cardiomyopathy for molecular analyses.- Distinct phenotype patterns of Ca2+ handling proteins in end-stage failing human hearts.- Apoptosis in the overloaded myocardium: potential stimuli and modifying signals.- Analysis of inherited causes of hypertrophic cardiomyopathy as part of clinical practice.- Molecular genetics of arrhythmogenic right ventricular cardiomyopathy.- Cardiomyopathy: Genetics in muscular dystrophies.- Molecular impact of ion channel mutations for the pathogenesis of long-QT (LQT) syndromes.- Acquired abnormal QT prolols4