Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria.
An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in your genetic toxicology tests. Genetic Toxicology Testing: A Laboratory Manual is an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own.
- Offers practical and consistent guidance on the most commonly-performed tests and procedures in a genetic toxicology lab
- Describes standard genetic toxicology assays, their methodology, reagents, suppliers, and analysis of their results
- Includes guidance on general approaches: formulation for in vitro assays, study monitoring, and Good Laboratory Practice (GLP)
- Serves as an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own lab
1. Introduction
2. Laboratory Design and Safety
3. Formulation
4. Bacterial Mutation Test
5. The Mouse Lymphoma TK Assay
6. In Vitro Micronucleus
7. In Vitro Chromosome Aberration
8. Rodent Micronucleus
9. Rodent Chromosome Aberration
10. Comet Assay
11. PigA Mammalian Erythrocyte Mutation
Reviewing genetic toxicology testing of chemicals in a Good Laboratory Practice (GLP) environment, this practical guide covers the most commonly used assays-from laborlĂ&
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