Handbook of Surface Plasmon Resonance RSC [Hardcover]

Surface plasmon resonance (SPR) plays a dominant role in real-time interaction sensing of biomolecular binding events. This book focuses on a total system description including optics, fluidics and sensor surfaces. It covers all commercial SPR systems in the market and is the first of its kind to fills a gap in the technical literature as no other handbook on SPR is currently available. All relevant aspects of present technology spanning a bridge between theory, instrumentation and applications are discussed. The book provides a thorough theoretical introduction, including kinetic models of biomolecular interactions as well as a practical guide for assay development. This excellent handbook provides comprehensive information with easy to use, stand-alone chapters and will be of great use to anyone one working with or affiliated to the technology.Chapter 1: Introduction to Surface Plasmon Resonance; Chapter 2: Physics of Surface Plasmon Resonance; Chapter 3: SPR Instrumentation; Chapter 4: Kinetic Models Describing Biomolecular Interactions at Surfaces; Chapter 5: Kinetic and Thermodynamic Analysis of Ligand-Receptor Interactions: SPR Applications in Drug Development; Chapter 6: Surface Chemistry in SPR Technology; Chapter 7: Measurement of the Analysis Cycle: Scanning SPR Microarray Imaging of Autoimmune Diseases; Chapter 8: Advanced Methods for SPR Imaging Biosensing; Chapter 9: Surface Plasmon Fluorescence Techniques for Bioaffinity Studies; Chapter 10: SPR Imaging for Clinical Diagnostics; Chapter 11: The Benefits and Scope of Surface Plasmon Resonance-based Biosensors in Food Analysis; Chapter 12: Future Trends in SPR TechnologySurface plasmon resonance (SPR) plays a dominant role in real-time interaction sensing of biomolecular binding events.The book is intended as a hands-on guide for all interested in SPRRichard B.M. Schasfoort is currently head of the Biochip Group at the University of Twente (UT), the Netherlands, as well as director of the BioMultianalytel“.