Homology Modeling: Methods and Protocols [Hardcover]

Knowledge about protein tertiary structure can guide experiments, assist in the understanding of structure-function relationships, and aid the design of new therapeutics for disease. Homology modeling is an in silico method that predicts the tertiary structure of an amino acid sequence based on a homologous experimentally determined structure.? In, Homology Modelling: Methods and Protocols experts in the field describe each homology modeling step from first principles, provide case studies for challenging modeling targets and describe methods for the prediction of how other molecules such as drugs can interact with the protein. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.

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Thorough and intuitive, Homology?Modelling: Methods and Protocols guides scientists in the available homology modeling methods.

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Knowledge about protein tertiary structure can guide experiments, assist in the understanding of structure-function relationships, and aid the design of new therapeutics for disease. This volume covers homology modeling steps all the way from first principles.

1. Classification of Proteins: Available Structural Space for Molecular Modelling

Antonina Andreeva

2. Effective Techniques for Protein Structure Mining

Stefan J. Suhrer, Markus Gruber, Markus Wiederstein, Manfred J. Sippl

3. Methods for Sequence-Structure Alignment

eslovas Venclovas

4. Force Fileds for Homology Modeling

Andrew J. Bordner

5. Automated Protein Structure Modeling with SWISS-MODELWorkspace andlăg