Urinary Tract Infections: Molecular Pathogenesis and Clinical Management [Hardcover]

Urinary Tract Infections

Second Edition

A comprehensive overview of clinically important infections of the urinary tract Urinary tract infections (UTIs) continue to rank among the most common infectious diseases of humans, despite remarkable progress in the ability to detect and treat them. Recurrent UTIs are a continuing problem and represent a clear threat as antibiotic-resistant organisms and infection-prone populations grow.

Urinary Tract Infections: Molecular Pathogenesis and Clinical Management brings the scientific community up to date on the research related to these infections that has occurred in the nearly two decades since the first edition. The editors have assembled a team of leading experts to cover critical topics in these main areas:

• clinical aspects of urinary tract infections, including anatomy, diagnosis, and management, featuring chapters on the vaginal microbiome as well as asymptomatic bacteriuria, prostatitis, and urosepsis
• the origins and virulence mechanisms of the bacteria responsible for most UTIs, including uropathogenic Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae
• the host immune response to UTIs, the rise of antibiotic-resistant strains, and the future of therapeutics

This essential reference serves as both a resource and a stimulus for future research endeavors for anyone with an interest in understanding these important infections, from the classroom to the laboratory and the clinic.

Contributors ix

Foreword xvii

Preface xix

I. Clinical Aspects of Urinary Tract Infections

1 Anatomy and Physiology of the Urinary Tract: Relation to Host Defense and Microbial Infection 3
Duane R. Hicl#"