Advances in Genetics [Hardcover]

Advances in Genetics increases its focus on modern human genetics and its relation to medicine with the merger of this long-standing serial with Molecular Genetic Medicine. This merger affirms theAcademic Press commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.C. Bell and N. Haites, The Peripheral Neuropathies and Their Molecular Genetics.
M.A. Brown, Tumor Suppressor Genes and Human Cancer.
J.F.Y. Brookfield, Genetic Redundancy.
P. Hutter, Genetics of HybridInviability in Drosophila.
D.J. Westenberg and M.L. Guerinot, Regulation of Bacterial Gene Expression.
D.D. Perkins, Chromosomes Rearrangements in Neurospora and Other Filamentous Fungi.
Subject Index.Advances in Genetics continues to present articles that are of interest to both human and molecular geneticists. This volume begins with an excellent review by Bell and Haites of the various classifications of, mechanisms of, and molecular diagnostic tests for peroneal muscular atrophy (or CMT). Melissa Brown critically examines the importance of tumor suppressor genes in human cancer and a number of the significant problems faced by cancer geneticists. The notion of genetic redundancy and whether functional redundancy can exist is investigated by John Brookfield in Chapter 3. Pierre Hutter discusses recent findings on speciation and the role of hybrid inviability in Drosophila. Westenberg and Guerinot review the effects of metal-regulated gene expression in cellular metabolism, pathogenicity, and toxicity. Finally, David Perkins provides extensive descriptions of chromosomal translocations in Neuraospora and other fungi and for use in executing genetic crosses.Sl#Ð