Biophysical Aspects of Transmembrane Signaling [Paperback]

The Impact of Environmental Signals on the Growth and Survival of Human T Cells.- Novel Single Cell Fluorescence Approaches in the Investigation of Signaling at the Cellular Level.- Non-Random Patterns of Membrane Proteins and Their Roles in Transmembrane Signaling.- Transmembrane Signals Mediated by IL-2 and IL-15 Control the Life and Death of Lymphocytes.- Single-Molecule Imaging of Diffusion, Recruitment, and Activation of Signaling Molecules in Living Cells.- Chemokine Signaling: The Functional Importance of Stabilizing Receptor Conformations.- Signaling and Reverse Signaling in the Tumor Necrosis Factor/TNF Receptor System.- Regulation of Immunoreceptor Activities: The Paradigm of the Type I Fc? Receptor.- Histamine Receptors and Signaling.- Signal Transduction by Ion Channels in Lymphocytes.

S?ndor Damjanovich initially studied medicine, and after he obtained his MD, he reoriented his focus in sciences and studied physics. After obtaining his three degrees (MD, Ph.D. and D.Sc) in Hungary, he travelled around the world studying and doing research in spectroscopy of proteins, molecular and cell biology of transmembrane signalling, and different aspects of membrane biophysics. While most of the time he preferentially applied luminescence methods, he also used other methods of investigation including flow cytometry, resonance energy transfer, steady state and time resolved fluorescence and phosphorescence spectroscopy, and most recently scanning force microscopy and near field optical microscopy in order to study cell surface phenomena. He and his co-workers have described a number of molecular patterns at the membrane of lymphocytes and other cells and are proponents of the belief that dynamic cell surface patterns and receptor superstructures govern immune processes and pharmacological interactions at the plasma membrane.

As a recipient of several major fellowships and visiting professorships, he has spent more than l£)