Bone Metastasis [Paperback]

A state-of-the-art review of the molecular underpinnings of bone-seeking cancers, current treatment approaches for them, and future therapeutic strategies. The authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. They also discuss the various strategies that appear to have promise and are currently deployed in treatment or are at the experimental stage.A state-of-the-art review of the molecular underpinnings of bone-seeking cancers, current treatment approaches for them, and future therapeutic strategies. The authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. They also discuss the various strategies that appear to have promise and are currently deployed in treatment or are at the experimental stage.Part I. Fundamental ConceptsOverviewSadmeet Singh and Gurmit SinghParathyroid Hormone-Related Peptide and MalignancyDavid GoltzmanVitamin D and Vitamin D Analogs in Cancer Progression and MetastasisRichard Kremer and Shafaat A. RabbaniRole of TGF-b and IGF in Tumor Progression and Bone MetastasesErin Giles and Gurmit SinghBiologic and Therapeutic Implications of Osteomimicry and Epithelial-Mesenchymal Transition in Prostate CancerWen-Chin Huang, Valerie Odero-Marah, and Leland W. K. ChungRoles of Immune-Cell-Derived Matrix Metalloproteinases in Tumor Growth and MetastasisKristina A. Szabo and Gurmit SinghContribution of Osteopontin to the Development of Bone MetastasisAlison L. Allan, Alan B. Tuck, Vivien H. C. Bramwell, Theodore A. Vandenberg, Eric W. Winquist, and Ann F. ChambersRole of Interleukin-11 in Osteolytic Bone l³&