Bound Carbohydrates in Nature [Paperback]

This 1994 book is a summary of Professor Waren's pivotal research on the special properties of bound carbohydrates in nature.Based on a series of six lectures delivered at the University of Siena and reflecting the author's career in biochemical research, this text considers the role that bound carbohydrates play in nature, the properties of membrane glycoproteins and the metabolism of sugars and sialic acids.Based on a series of six lectures delivered at the University of Siena and reflecting the author's career in biochemical research, this text considers the role that bound carbohydrates play in nature, the properties of membrane glycoproteins and the metabolism of sugars and sialic acids.Bound carbohydrates are an important and fascinating topic in biochemical and cancer research. Based on a series of invited lectures, this book focuses on the special role that bound carbohydrates play in nature and reflect the author's distinguished career in biochemical research. Some other topics covered are the properties of membrane glycoproteins, involved in the resistance of cells to drugs, and the metabolism of sugars and sialic acids, both of which form a pivotal role in the author's studies. The book chronicles just some of the huge advances that have been made in biochemistry over the past few decades.1. Introduction, history, microheterogeneity of bound carbohydrates; function of bound carbohydrates; inducible changes in bound carbohydrates; programmed changes in bound carbohydrates; a possible role for bound carbohydrates; 2. Sialic acids; distribution of sialic acids in nature; the metabolism of hexamines and sialic acids; metabolic control of hexosamines and sialic acids; asparagine N-glycosylation; processing of lysomal enzymes; biosynthesis of O-linked oligosaccarides; modification of sialic acids; sialidases; genetic metabolic disorders involving sialic acids, glycosidases, bound carbohydrates in malignancy; 3. Multidrug resistance, properties of P-glycoproteinlӜ