Cytokine Knockouts [Hardcover]

Carrying on the high standards of the much praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous often-surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology and physiology. For those not familiar with cytokine research, the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research.Carrying on the high standards of the much praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous often-surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology and physiology. For those not familiar with cytokine research, the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research.Part I. Cytokine Knockouts in Models of Human DiseaseCytokine Knockouts in InflammationPietro GhezziThe Use of Cytokine Knockouts to Study Host Defense Against InfectionCharles A. DinarelloThe Use of Cytokine Knockouts in Animal Models of Autoimmune DiseaseAlfons Billiau, Hubertine Heremans, and Patrick MatthysThe Use of Cytokine Knockout Mice in Cancer ResearchRobert H. Wiltrout, Jon M. Wigginton, and William J. MurphyThe Use of Cytokine Knockout Mice in NeuroimmunologyGiamal N. Luheshi, Emmanuel Pinteaux, and Herv? BoutinPart II. Cytokine Knockout MiceThe Role of IL-1 in the Immune SystemSusumu Nakae, Reiko Horai, Yutaka Komiyama, Aya Nambul#K