The book highlights experimental autoimmune encephalomyelitis which is the most commonly used experimental model. It is entirely based on the model of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). The book incorporates a very fine and deep analysis of recent and vastly used EAE models. Furthermore, the parts explaining novel probationary therapeutic advances show the applications of the EAE model for MS search. Latest research themes have been contributed by the learned and experienced international faculty, which testify the pivotal role of EAE in research around the globe. This text will contribute to knowledge of students and researchers by giving them detailed information about the subject and pushing them forward in their research.