Genetics of Colorectal Cancer [Paperback]

Genetic susceptibility refers to how variations in a persons genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.

This volume explores the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers.

Genetic susceptibility refers to how variations in a persons genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.

Section One  Epidemiology and Models of Colorectal Cancer Chapter 1. Colorectal Cancer  Epidemiology. John D. Potter and David Hunter. Chapter 2. Mouse Models of Intestinal Cancer. Erin M. Perchiniak and Joanna Groden. Section Two  Pathways to Colorectal Cancer Chapter 3. The Chromosomal Instability Pathway and APC Gene Mutation in Colorectal Cancer. Robert Gryfe and Steven Gallinger. Chapter 4. DNA Methylation in Colorectal Cancer: multiple facets of tumoriglÓ3