Influenza Vaccines for the Future [Hardcover]

The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses in the laboratory using reverse genetics. This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but is also designed to be a resource to face the present H1N1 pandemic and to plan for long-term global and sustainable solutions.This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but it is also designed to be a resource to face the present H1N1 pandemic and to plan for long term global and sustainable solutions.EVOLUTION AND EPIDEMIOLOGY.- Influenza Virus: The Biology of a Changing Virus.- The Epidemiology of Influenza and its Control.- Epidemiology of Influenza in Tropical and Sub-Tropical Low Income Regions.- The Origin and Evolution of H1N1 Pandemic Influenza Viruses.- The Emergence of 2009 H1N1 Pandemic Influenza.- IMMUNITY AND VACCINE STRATEGIES.- Influenza Vaccines have Short but Illustrious History of Dedicated Science Enabling the Rapid Global Production of A/Swine (H1N1) Vaccine in the Current Pandemic.- Influenza and Influenza Vaccination in Children.- The Immune Response to Influenza A Viruses.- Correlates of Protection Against Influenza.- The Role of Animal Models in Influenza Vaccine Research.- Live Attenuated Influenza Vaccine.- Cell Culture-Derived Influenza Vaccines.- Conserved Internal Proteins as Potential Universal Vaccines.- Adjuvants for Influenza Vaccines: The Role of Oil-in-Water Adjuvants.- Lesson Learned from Clinical Trials in 1976 and 1977 with Vaccines for the Newlyl“/