Laser-Driven Particle Acceleration Towards Radiobiology and Medicine [Hardcover]

This book deals with the new method of laser-driven acceleration for application to radiation biophysics and medicine. It provides multidisciplinary contributions from world leading scientist in order to assess the state of the art of innovative tools for radiation biology research and medical applications of ionizing radiation. The book contains insightful contributions on highly topical aspects of spatio-temporal radiation biophysics, evolving over several orders of magnitude, typically from femtosecond and sub-micrometer scales. Particular attention is devoted to the emerging technology of laser-driven particle accelerators and their application to spatio-temporal radiation biology and medical physics, customization of non-conventional and selective radiotherapy and optimized radioprotection protocols.Part I Laser driven particle acceleration: From experiments to devices.- Ultra-intense lasers and particle acceleration: past, present and future.- Laser-plasma interactions and stable production of ultrashort relativistic electron bunches.- Proton acceleration: state of the art and perspectives.- Recent progress on laser-driven particle acceleration in China.- Multi-GeV regime of Laser-Wakefield dual-stage accelerator.- Dosimetry of pulsed particle sources.- Part II Biophysical studies with laser driven particle sources.- High-energy radiation femtochemistry.- High-dose rate exposure of biological matter.- Comparative radiobiological tests with RF versus Laser-driven electron bunches.- Ultrafast X-ray imaging of living cells.- Biological responses triggered by laser-driven sources (proton and X-ray).- Part III Synchrotron, ion accelerator and microbeam.- Synchrotron source: dosimetry and pre-clinical trials.- Microbeam radiation and biological responses.- Cyberniffe, dose fractioning for clinical protocols.- Protontherapy of cancer.- Ion radiotherapy: state of the art and future.

Antonio Giulietti is a physicist operating at INO (NationalInstitute of OpticslĂ,