Mesenchymal Stromal Cells as Tumor Stromal Modulators [Paperback]

Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies.

Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses.

• Explores the biology of mesenchymal stromal cells (MSCs) and tissue related function
• Discusses the bidirectional communication between tumor stroma and MSCs derived from bone marrow, from adipose tissue and from other tissue types
• Provides in-depth analysis of the effects of MSCs on key processes that regulate disease progression, such as angiogenesis, metastatic potential, invasion, proliferation, tumor immune privileges

1. What are Mesenchymal Stromal Cells? Origin and Discovery of Mesenchymal Stromal Cells Jorge Domenech

2. Mesenchymal Stem/Stromal Cells from Adult Tissues Regina Coeli dos Santos Goldenberg, Debora Bastos Mello and Karina Dutra Asensi

3. Mesenchymal Stem/Stromal Cells from Neonatal Tissues Alp Can, Zeynep Gulhan Yigman

4. Mesenchymal stem/Stromal Cells Derived from Pluripotent Stem Cells Carlos Luzzani, Santiago G. Miriuka