Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds [Paperback]

Proceedings of a NATO ASI held in ?esme (Izmir), Turkey, August 27-September 7, 1989.Cytochrome P450-Dependent Monooxygenase: An Overview.- The Flavin-Containing Monooxygenase (EC 1.14.13.8).- Multiple Forms of Rabbit Cytochrome P450: Comparison of Chemical, Physical, Immunological and Biocatalytic Properties.- Primary Structures and Regulation of Cytochrome P450 Isozymes 2 (IIB) and 5 (IVB) and the Flavin-Containing Monooxygenase in Rabbit Liver and Lung.- Insect Cytochrome P450.- I. Membrane Topology of Cytochromes P450: Elements and Measurement by Spectroscopic Techniques.- II. Membrane Topology of Cytochromes P450: Oligomers and Cooperativity.- NADPH-Dependent Cytochrome P450 Reductase A. Y. H. Lu.- Essential Features of NADH Dependent Cytochrome b5 Reductase and Cytochrome b5 of Liver and Lung Microsomes.- Electron Transfer from Cytochrome b5 to Cytochrome P450.- Functional Aspects of Protein-Protein Interactions of Cytochrome P450, Cytochrome b5 and Cytochrome P450 Reductase.- Posttranslational Modification by Phosphorylation: Control of Cytochrome P450 and Associated Enzymes.- Physiological and Pathophysiological Alterations in Rat Hepatic Cytochrome P450.- Ontogenesis of Liver Cytochromes P450.- Mechanism of Steroid Hormome Action A. Berkenstam.- Xenobiotic Regulation of Cytochrome P450 Gene Expression.- Prostanoid Metabolism and Biologically Active Product Formation.- Role of Cytochrome P450 in the Anabolism and Catabolism of Endobiotics.- Interactions of Estrogenic Pesticides with Cytochrome P450.- Effects of Inhibitors on the P450-Dependent Metabolism of Endogenous Compounds in Fungi, Protozoa, Plants and Vertebrates.- Mechanism of Metabolic Activation of Nitroimidozoles.- Benzene Metabolism R. Snyder.- Mechanisms of Benzene Toxicity.- Hematotoxicity, Leukemogenecity and Carcinogenecity of Chronic Exposure to Benzene.- Epoxide Hydrolase Isoenzymes and Their Individual Contribution to the Control of Toxic Metabolites.- Role of the Weil-Known Basic and Recl³+