New Directions in Affective Disorders [Paperback]

Contributors.- I Pathogenesis of Affective Disorders and Basic Mechanisms of Drug Action.- I.A. Animal Models and Antidepressant Predictability.- 1 Neurochemical and Behavioral Effects of Stress: A Rat Model of Depression.- 2 Study of Olfactory Bulbectomized Rats: Revelations About Major Depressive Disorder.- 3 Bilaterally Olfactory Bulbectomized Rat Model of Depression.- 4 Behavioral Despair: Past and Future.- 5 Genetically Nervous and Normal Pointer Dogs: Relation Between Hearing and Behavioral Abnormalities.- 6 Agonist-Induced Down-Regulation of ?1-Adrenergic Receptors: Possible Biochemical Rationale for Novel Antidepressants.- 7 Behavioral Pharmacology and Clinical Antidepressant Effects of ?-Adrenergic Agonists.- I.B. Monoamines and Neuropeptides.- 8 Beyond Nosology in Biological Psychiatry: Prolegomena of a Functional Psychopathology.- 9 Serotonergic Aspects of Agonistic Behavior.- 10 Noradrenergic and Serotonergic Dysfunction in the Affective Disorders.- 11 Neuropeptides and Affective Disorders.- 12 Antemortem and Postmortem Measures of Central Nervous System Serotonergic Function: Methodological Issues.- 13 Postmortem Investigation of Serotonergic and Peptidergic Hypotheses of Affective Illness.- I.C. Cholinergic Mechanisms.- 14 Genetic Animal Model of Depression with Cholinergic Supersensitivity.- 15 Impact of the Cholinergic System on the Hypothalamic-Pituitary- Adrenocortical Axis and on REM Sleep.- 16 Relation Between m-Cholinoceptor Density on Human Blood Cells and Psychological Predisposition Factors for Depression.- 17 Differential Effects of Physostigmine in Alcoholics, Alcoholics with Affective Disorder, and Normal Individuals.- I.D. Basic Mechanisms of Antidepressants and Anxiolytics.- 18 Serotonin/Norepinephrine/Steroid Receptor Link in Brain and the Mode of Action of Antidepressants: Update and New Perspectives.- 19 Presynaptic Sites of Antidepressant Action: Monoamine Transport Systems and Release-Modulating Autoreceptors.- 20 LightDark-Relatedló¹