Oral Mucositis [Paperback]

Treatment tolerance is a challenge for most cancer patients, and it is therefore essential that healthcare professionals (HCP) are quick to recognize adverse events and implement management strategies to address them. This pocket book provides an in-depth guide to the epidemiology, diagnosis and management of oral mucositis, a common adverse event of chemotherapy.Introduction.- The pathobiology of oral mucositis.- The epidemiology and risk assessment of mucositis.- Health and economic consequences of mucositis.- The elements of examination of the oral cavity.- A comparison and assessment of scoring scales for mucositis.- Patient-reported outcomes.- Non mucositis mouth lesions in patients being treated for cancer.- Current approaches to the management of oral mucositis.Stephen T. Sonis, DMD, DMSc received his DMD from Tufts University, and then entered a combined doctorate and clinical specialty training program at Harvard University. Following completion of his degree and residency, he was awarded a Knox Fellowship to study tumor immunology at Oxford University, UK. He returned to the United States to accept joint positions at the Peter Bent Brigham Hospital, Sidney Farber Cancer Center, and the Harvard School of Dental Medicine. Dr. Sonis research converged on studies to define the biology and clinical significance of cancer regimen-related mucosal toxicities. The results of his studies on the molecular and cellular pathogenesis of mucositis have established the basis of a mechanistic paradigm for epithelial injury, and have provided treatment targets for biological and pharmaceutical development. Recognizing that genetics play a role in patient risk for mucositis and other toxicities, Dr. Sonis and his collaborators have identified specific canonical pathways that are critical in toxicity development and have used these to form the basis for models of gene-based risk prediction. With the application of network theory to cancer-related toxicities, Dr. Sonis and hilă#