The Neuregulin-I/ErbB Signaling System in Development and Disease [Paperback]

Neuregulins are EGF-like growth and differentiation factors that interact with tyrosine kinase receptors of the ErbB family. Neuregulin signals are also involved in the development diseases including breast cancer, heart disease and the pathogenesis of schizophrenia. This book reviews the biology of Neuregulins and their receptors and summarizes recent research, which has established crucial functions of this signaling system during development and disease.

Introduction  Molecular control of development.- Biology of the Neuregulin/ErbB signaling network.- Neuregulins and their receptors.- Developmental functions of the Neuregulin-1/ErbB signalling pathway.- Interacting molecules  the Sox10/ErbB connection.- NRG-1/ErbB signals and disease.- Abbreviations.- References.- Subject index

Neuregulins are EGF-like growth and differentiation factors that interact with tyrosine kinase receptors of the ErbB family. this signailing system has a wide range of functions during development of the nervous system, the heart, and the mammary gland. Furthermore, Neuregulin signals are also involved in the development of human diseases including breast cancer, heart disease and the pathogenesis of schizophrenia.

This monograph reviews the biology of Neuregulins and their receptors and summarizes recent research, which has established crucial functions of this signaling system during development and disease. 

Discusses the role of Neuregulins during development of the nervous system, the heart, and the mammary gland

Shows their involvement in development of breast cancer, heart disease and the pathogenesis of schizophrenia

Reviews the biology of Neuregulins and their receptors and summarizes recent research