VEGF and Cancer [Paperback]

VEGF and Cancer is a comprehensive and up to date review of current knowledge on the role of vascular endothelial growth factor (VEGF) in cancer.
Key Features:
-Discussion of VEGF as potent angiogenic factor and its role in tumor angiogenesis,
-Review of the biology, molecular properties and regulation of VEGF,
-Discussion of the role of VEGF in a range of different tumor types, both solid tumors and haematological cancers,
-Review of the therapeutic potential of different approaches to block VEGF,
-Review of recent evidence that in addition to its role as an endothelial cell mitogen, VEGF may also be an autocrine growth factor for tumor cells, regulating survival and invasion.

This book is aimed at scientists new to angiogenesis and VEGF biology and provides new information for established researchers and scientists. It will also be a useful text for clinicians interested in anti-angiogenic therapy for treatment of human cancers.

1. VEGF and Its Receptors.- Activities of VEGF.- VEGF Isoforms.- Regulation of VEGF Gene Expression.- The VEGF Receptors.- Role of VEGF in Physiological Angiogenesis.- Role of VEGF in Pathologic Conditions.- Therapeutic Implications and Perspectives.- 2. Hypoxic Regulation of VEGF.- Transcriptional Regulation of VEGF.- Post Transcriptional Regulation of VEGF.- Abnormalities in the Hypoxic Regulation of VEGF.- 3. Molecular Mechanisms of VEGF-Induced Angiogenesis.- Angiogenesis.- The Role of Vascular Endothelial Growth Factor in Angiogenesis.- The VEGF Signal Cascade in Angiogenesis.- 4. Crosstalk between VEGF and Bd-2 in Tumor Progression and Angiogenesis.- Angiogenic Potential of Tumor Cells Overexpressing Bcl-2.- Role of Bcl-2 in VEGF-Promoted Survival of Tumor Cells.- Role of Bcl-2 in Endothelial Cells.- Clinical Relevance of VEGF and Bcl-2 Expression.- 5. Vascular Endothelial Growth Factor in Breast Cancer.- VEGl3ˆ