Endodontic microscopy and its clinical implication can be categorized into six areas according to its role in diagnosis, non surgical endodontics, surgical endodontics, documentation and patient education, marketing and in revitalization of the clinicians' career.Exact therapy requires exact vision. High-quality endodontic therapy is the basis for long-term function and biologic success, ensuring that patients remain free of pain. State-of-the-art equipment and thorough clinical know-how are vitally important to reach this goal. Today, a small but growing number of clinicians are providing endodontic and endo-restorative treatments based on direct microscopic visualization of the pulp chamber and coronal portions of canal systems. This huge shift in clinical accuracy from low magnification tactile-driven endodontics to vision-based endodontics is bringing a revolution to the field of endodontics with greater success rate.