Treatment of Glioma [Paperback]

Malignant glioma is generally considered one of the most therapeutically difficult cerebral tumors. This book deals with many aspects of gliomas, including factors related to incidence and epidemiology, and surveys the history of glioma therapies. Experimental studies carried out by the Sendai Group of Neurosurgeons are reported, together with the results of many clinical studies of RAFP therapy. This particular theorapy involves the administration of radiation treatment and three chemical compounds: ACNU, Futraful and PSK. A recent technique for evaluating the effectiveness of therapy based on MRI diagnostic methods is introduced. This book thus offers valuable information and guidelines for future developments in treatment.Malignant glioma is generally considered one of the most therapeutically difficult cerebral tumors. This book deals with many aspects of gliomas, including factors related to incidence and epidemiology, and surveys the history of glioma therapies. Experimental studies carried out by the Sendai Group of Neurosurgeons are reported, together with the results of many clinical studies of RAFP therapy. This particular theorapy involves the administration of radiation treatment and three chemical compounds: ACNU, Futraful and PSK. A recent technique for evaluating the effectiveness of therapy based on MRI diagnostic methods is introduced. This book thus offers valuable information and guidelines for future developments in treatment.I. Statistical Analysis.- 1. Epidemiology and Statistical Analysis of Gliomas.- 2. Statistical Considerations of Therapeutic Results in Glioblastoma.- II. Basic Studies.- 3. Combined Effects of Radiation, ACNU, and 5-FU on Gliomas: An Experimental Combination Therapy.- 4. The Pharmacokinetics of ACNU in Patients with Malignant Brain Tumor.- 5. The Effects of Induced Hypertension on the Uptake of ACNU in Experimental Brain Tumor.- 6. A Study of Intratumoral Oxygen Pressure in Brain Tumors.- III. Clinical Studies.- 7. An Outlilc)