Lens Epithelium and Posterior Capsular Opacification [Hardcover]

This book is the first to summarize the current knowledge of the cell biology of lens epithelial cells in relation to and in the development of posterior capsular opacification (PCO). PCO remains the most common long-term complication of modern cataract surgery, occurring months or years after cataract surgery, unlike most other complications that tend to arise during or soon after the procedure. Opacification of the posterior capsule appears to be linked to lens epithelial cells that are left behind in the eye during cataract removal. These cells proliferate, migrate across the posterior lens capsule, and undergo changes that result in fibrous or pearl-type opacities in the capsule.

The first section of the text explains the molecular mechanism and biology of lens epithelial cells that lead to the incidence of PCO. In the second part, in addition to a description of the mechanism and pathological condition of PCO, surgical methods and devices for preventing PCO are discussed in detail. Lens Epithelium and Capsular Opacification will benefit not only young clinical residents and junior researchers, but also established faculty in the clinical or basic academic field.

PART I: Lens Epithelial Cell Biology.- Chapter 1. From Zygote to Lens: Emergence of the Lens Epithelium.- Chapter 2. Cell Biology of Lens Epithelial Cells.- Chapter 3. The Lens Capsule  Synthesis, Remodeling and MMPs.- Chapter 4. Lens Epithelial Cell Proliferation.- Chapter 5. Growth Factor Signaling in Lens Fiber Differentiation.- Chapter 6. Lens-Specific Transcription Factors and Their Roles in Diagnosis and Treatment of Human Congenital Cataract.- Chapter 7. Lens Regeneration.- Chaptel£.