Leukemia and Lymphoma Detection of Minimal Residual Disease [Hardcover]

In Leukemia and Lymphoma: Detection of Minimal Residual Disease, hands-on experts describe and discuss the minimal residual disease (MRD) methods they have successfully pioneered for leukemias and lymphomas. They apply reverse transcription PCR (RT-PCR) to acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), and acute promyelocytic leukemia (APL). Other PCR methods are used for Non-Hodgkin's Lymphoma and for the monitoring of follicular lymphoma. Additional chapters address the use of real-time quantitative PCR (RQ-PCR), the emergent method of choice, in patients with acute lymphoblastic leukemia (ALL), the evaluation of MRD techniques in clinical trials, and the application of flow cytometry techniques.In Leukemia and Lymphoma: Detection of Minimal Residual Disease, hands-on experts describe and discuss the minimal residual disease (MRD) methods they have successfully pioneered for leukemias and lymphomas. They apply reverse transcription PCR (RT-PCR) to acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), and acute promyelocytic leukemia (APL). Other PCR methods are used for Non-Hodgkin's Lymphoma and for the monitoring of follicular lymphoma. Additional chapters address the use of real-time quantitative PCR (RQ-PCR), the emergent method of choice, in patients with acute lymphoblastic leukemia (ALL), the evaluation of MRD techniques in clinical trials, and the application of flow cytometry techniques.Flow-Cytometry Methods for the Detection of Residual LeukemiaRichard Ratei and Wolf-Dieter LudwigFlow-Cytometry-Based Studies of Minimal Residual Disease in Children with Acute Lymphoblastic LeukemiaDario CampanaPCR Methods for the Detection of Minimal Residual Disease in Childhood Acute Lymphoblastic LeukemiaGeoffrey NealeStatistical Considerations in the Analysis of Minimal Residual DiseaseDennis A. Johnston and Theodore F. ZipfThe Application of Minimal Residual Disease Detection Methodology to the Clinical Decision-Making ProcessTheodorlS"