The Living Brain and Alzheimers Disease [Paperback]

From large cross-sectional studies of autopsy material, it seems as if a time course of Alzheimer's Disease, at least on average, can be mapped out: a pattern of hierarchical vulnerability for neuronal loss and neurofibrillary tangles beginning in medial temporal lobe structures proceeding through association areas. Plaques follow their own temporal course, with widespread cortical deposits occurring even early in a disease process. The whole process may well take twenty years, the first half of which may be without overt symptoms.

From large cross-sectional studies of autopsy material, it seems as if a time course of Alzheimer's Disease, at least on average, can be mapped out: a pattern of hierarchical vulnerability for neuronal loss and neurofibrillary tangles beginning in medial temporal lobe structures proceeding through association areas. Plaques follow their own temporal course, with widespread cortical deposits occurring even early in a disease process. The whole process may well take twenty years, the first half of which may be without overt symptoms.

Neuropathology of Alzheimers Disease as Seen in Fixed Tissues.-Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimers Disease.- The Living Brain and Alzheimers Disease.- In Vivo Imaging of Alzheimer Pathology in Transgenic Mice Using Multiphoton Microscopy.- In Vivo Magnetic Resonance of Amyloid Plaques in Alzheimers Disease Model Mice.- Measuring Progression in Alzheimers Disease Using Serial MRI: 4D MRI.- Validating MRI Measures of Disease Stage and Progression in Alzheimers Disease.- Dynamic Mapping of Alzheimers Disease.- Development of Benzothiazole Amyloid-Imaging Agent (PIB) in Alzheimers Disease Patients and Healthy Volunteers.- Mild Cognitive Impairment (MCI): Predicting Conversion to Clinically Probable Alzheimers Disease with Fluoro-Deoxy-Glucose PET.- Subject Index

How can we link the critical observations performed at autopsy with the evelcÑ