Mass Spectrometry for Chemists and Biochemists [Paperback]

This second, fully-updated edition on mass spectrometry forms an ideal undergraduatepostgraduate and research textbook.This second edition includes new methods and applications that have developed in the past ten years. Powerful methods combining mass spectrometry with newer separation techniques and analysis of once difficult polar and large-mass compounds such as proteins are discussed.This second edition includes new methods and applications that have developed in the past ten years. Powerful methods combining mass spectrometry with newer separation techniques and analysis of once difficult polar and large-mass compounds such as proteins are discussed.This book describes the full range of techniques and applications used in mass spectrometry. Researchers in universities and industry laboratories use this versatile technique because of its ability to identify a minute amount of material quickly. The technique solves analytical problems in a huge variety of fields. The authors adopt an instructional approach and make use of recent examples to illustrate important points. This second edition includes new methods and applications that have developed in the past ten years. The authors discuss powerful methods combining mass spectrometry with newer separation techniques, the increased use of computers, and analysis of once difficult polar and large-mass compounds such as proteins using new ionization methods. The book, requiring no previous knowledge of mass spectrometry, is an ideal teaching text at both the undergraduate and postgraduate level, and will also be of considerable interest to research workers.Introduction; Acknowledgements; Table of quantities; List of abbreviations; 1. The mass spectrum; 2. Instrument design; 3. Methods of ionization; 4. Computers in mass spectrometry: data systems; 5. Combined chromatography and mass spectrometry; 6. Uses of derivatization; 7. Quantitative mass spectrometry; 8. Metastable ions and mass spectrometry; 9. Theory of mal­