Membrane Structural Biology: With Biochemical and Biophysical Foundations [Hardcover]

An updated edition on membrane biology, providing new high resolution structures of membrane proteins and insights into how they function.This textbook provides a strong foundation and comprehensive overview for students and an invaluable synthesis of cutting-edge research for working scientists. This second edition is expanded to include and make accessible all the latest developments and topics, with more than twenty new high resolution structures. Links between membrane research and human health are emphasised throughout.This textbook provides a strong foundation and comprehensive overview for students and an invaluable synthesis of cutting-edge research for working scientists. This second edition is expanded to include and make accessible all the latest developments and topics, with more than twenty new high resolution structures. Links between membrane research and human health are emphasised throughout.This textbook provides a strong foundation and a clear overview for students of membrane biology and an invaluable synthesis of cutting-edge research for working scientists. The text retains its clear and engaging style, providing a solid background in membrane biochemistry, while also incorporating the approaches of biophysics, genetics and cell biology to investigations of membrane structure, function and biogenesis to provide a unique overview of this fast-moving field. A wealth of new high resolution structures of membrane proteins are presented, including the Na/K pump and a receptor-G protein complex, offering exciting insights into how they function. All key tools of current membrane research are described, including detergents and model systems, bioinformatics, protein-folding methodology, crystallography and diffraction, and molecular modeling. This comprehensive and up-to-date text, emphasising the correlations between membrane research and human health, provides a solid foundation for all those working in this field.Dedication; Preface; 1. Introductiolă°