Molecular and Cellular Signaling [Paperback]

Makes connections between diseases, drugs and signaling in those chapters not specifically devoted to pathogens.

Reviews background in first 5 chapters then offers chapters on cancers and apoptosis and on bacteria and viruses.

Signaling in the immune, endocrine (hormonal) and nervous systems covered along with cancer, apoptosis and gene regulation.

Each chapter ends with a problem section to facilitate discussion.

1. Introduction 2.The Control Layer 3. Exploring Protein Structure and Function 4. Macromolecular Forces 5. Protein Folding and Binding 6. Stress and Pheromone Responses in Yeast 7.Two-Component Signaling Systems 8. Organization of Signal Complexes by Lipids, Calcium and Cyclic Amp 9. Signaling by Cells of the Immune System 10. Cell Adhesion and Motility 11. Signaling in the Endocrine System 12. Signaling in the Endocrine and Nervous System through GPCRs 13. Cell Fate and Polarity 14.Cancer 15. Adoptosis 16. Gene Regulation in Eukaryotes 17. Cell Regulation in Bacteria 18. Regulation by Viruses 19. Ion Channels 20. Neural Rhythms 21. Learning and Memory

Martin Beckerman, Ph.D. is Senior Scientist at the Department of Energy/National Nuclear Security Administrations Y-12 National Security Complex in Oak Ridge, TN. Prior to assuming his current position at the Y-12 NSC, Dr. Beckerman held teaching and research positions at the Weizmann Institute of Science, the University of Rochester, the Massachusetts Institute of Technology, the University of Tennessee and the Oak Ridge National Laboratory. He has over 130 publications, 1400 citations, and is the author of a previously published book entitled Adaptive Cooperative Systems.

A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kindlӥ