Myeloproliferative Neoplasms: Biology and Therapy [Hardcover]

This succinct resource provides an ideal balance of the biology and practical therapeutic strategies for classic and non-classic BCR-ABL-negative myeloproliferative neoplasms. Utilizing current World Health Organization nomenclature, classification, and diagnostic criteria, international experts have assembled to convey the most up-to-date knowledge in this rapidly evolving field. The opening chapters cover the diagnosis and classification, genetics, cytogenetic findings, and prognostic factors of MPNs. Further chapters explore therapies specific to the different disease entities, including polycythemia vera, essential thrombocytopenia, myelofibrosis, and eosinophilic disorders, and mastocytosis. Unique areas of discussion include JAK2 inhibitor therapy, hematopoietic stem cell transplantation, and blastic transformation. A valuable reference for practicing hematologists, this forefront book enriches our understanding of recent discoveries and their impact on conventional and investigational treatments.Chapter 1 - Diagnosis and Classification of the BCR-ABL--negative Myeloproliferative Neoplasms James W. Vardiman and Carlos E. Bueso-RamosChapter 2 - Genetics of the Myeloproliferative NeoplasmsOmar Abdel-Wahab and Ross L. LevineChapter 3 - Cytogenetic Findings in Classic Myeloproliferative NeoplasmsJohn T ReillyChapter 4 - Prognostic Factors in Classic Myeloproliferative NeoplasmsFrancisco Cervantes and Juan-Carlos Hern?ndez-BoludaChapter 5 - Therapy of Polycythemia Vera and Essential ThrombocythemiaGuido Finazzi and Tiziano BarbuiChapter 6 - Conventional and Investigational Therapy for Primary MyelofibrosisGiovanni BarosiChapter 7 - Hematopoietic Cell Transplantation for MyelofibrosisDaniella M.B. Kerbauy and H.Joachim DeegChapter 8 - JAK2 Inhibitors as Therapy for Classic Myeloproliferative NeoplasmsFabio P S Santos and Srdan VerstovsekChapter 9 - Blastic Transformation of Classic Myeloproliferative NeoplasmsRuben A. MesaChapter 10 - Eosinophilic Disorders: Dil£Ý