The Neuroendocrine Immune Network in Ageing [Hardcover]

The book describes the mechanisms involved in the maintenance of neuroendocrine-immune interactions in ageing. The lack of this maintenance leads to the appearance of age-related diseases (cancer, infections, dementia) and subsequent disability. The capacity of some hormones or nutritional factors in restoring and remodelling the neuroendocrine-immune response during ageing is reported presenting possible new anti-ageing strategies in order to reach healthy ageing and longevity.I. Introduction.
Evolutionary aspects for the neuroendocrine immune network and ageing (R.H. Straub).

II. Ageing of the immune system.
Immunosenescence (R. Solana, G. Pawelec). Zinc-binding proteins (metallothionein and ?-2 macroglobulin) as potential biological markers of immunosenescence (E. Mocchegiani et al.). Neutrophil ageing and immunosenescence (S.K. Butcher et al.). Apoptosis and ageing (A. Larbi et al.). MHC-unrestricted cytotoxicity in ageing (M. Provinciali, A. Donnini, R.E. Francesca). Major histocompatibility complex polymorphisms and ageing (G. Candore et al.).

III. Ageing of the endocrine system.
Neuroplascticity in the human hypothalamus during ageing (M.A. Hofman, D.F. Swaab). The role of growth hormone signalling in the control of ageing (A. Bartke et al.). Ageing and the adrenal cortex (V. Lamounier-Zepter, S.R. Bornstein). Hormonal changes in ageing men (E. Plas, S. Madersbacher, P. Berger). Ageing and the endocrine circadian system (Y. Touitou, E. Haus). Melatonin rhythms, melatonin supplementation and sleep in old age (R.F. Riemersma et al.).

IV. Ageing of the nervous system.
Age-related changes of the human autonomic nervous system (M. Agelink, R. Malessa, D. Ziegler). Age-rl³G