Opiate Receptors and Antagonists: From Bench to Clinic [Paperback]

Comprehensive and authoritative, Opioid Receptors and Antagonists: From Bench to Clinic offers neuroscientists, pharmacologists and interested clinicians a unique survey of the extensive and diverse research efforts currently employed with opioid antagonists to develop novel innovative drug therapies.

• Summarizes the present understanding of the chemistry, pharmacology and molecular biology of opioid receptors and their subtypes
• Highlights differences and similarities between the opioid pharmacology of animals and human
• Describes current and potential therapeutic areas for opioid antagonists, including substance abuse, alcohol and ingestive behaviors, behavioral disorders and other medical indications, supported by nonclinical and clinical evidence
• Focuses on the development of exciting and innovative drug delivery approaches that are being used with opioid antagonists for the above medical indications

This volume offers a comprehensive view of recent work on opioid antagonist applications and uses in various clinical treatments. Emphasis is placed on disorders of the reward system. The book also illuminates prospects for future research.

The evolution in our understanding of opioid receptors and their subtypes is in- mately linked to the development of new pharmacological treatments for diseases/ disorders as diverse as addiction, self-injurious behavior, pain, cancer, infl- mation, eating disorders, traumatic injury, pruritis, and movement disorders. These potential treatments involve both novel chemical entities and classic opioid antagonists with improved drug delivery systems. The contributions contained in Opioid Receptors and Antagonists: From Bench to Clinic represent the efforts from some of the leading internatioló,