Pharmacokinetics for the Pharmaceutical Scientist [Hardcover]

Major presentation of pharmacokinetics by a leading international expert. Methods for: estimating drug disposition parameters from data obtained after intravascular or extravascular drug administration, estimating rate and extent of drug bioavailability, and comparing rate and extent of drug availability following administration of several different dosage forms of a drug.Simple Linear Models

More Complicated Linear Models

Complicated Linear Models

Linear Multicompartment Disposition Parameters from Extravascular Downslope
C,T Data

Noncompartmental and System Analysis Linear Multiple Dose Equations

Simple Nonlinear Models

More Complicated Nonlinear Models

Urinary Excretion

Absorption Analysis and Bioavailability

Physiological Pharmacokinetics

Relationship between Physiologically Based Flow Models and Usual Compartment
Models

Protein Binding

Pharmacokinetic

Pharmacodynamic Modelling

Metabolic Kinetics

Laplace Derivation of Linear Pharmacokinetic Equations

Measures of Fit

Appendix

Index


175 Figures and Schematics, 51 Tables, 134 References