Portal Hypertension Pathobiology, Evaluation, and Treatment [Hardcover]

A cutting-edge review of the latest findings on key scientific topics and the best strategies for evaluation and management of portal hypertension in the clinic. Writing in an easy-to-read style, the authors review its pathobiology, the progress being made in its experimental understanding, the methodologies to assess it in humans, the treatment of its complications (esophageal varices, ascites, and hepatorenal syndrome), and its treatment in special circumstances (during pregnancy, in children, or when the portal vein is blocked). They also provide in-depth coverage of the pros and cons of the various therapeutic choices available to the clinician managing patients with complicated portal hypertension.A cutting-edge review of the latest findings on key scientific topics and the best strategies for evaluation and management of portal hypertension in the clinic. Writing in an easy-to-read style, the authors review its pathobiology, the progress being made in its experimental understanding, the methodologies to assess it in humans, the treatment of its complications (esophageal varices, ascites, and hepatorenal syndrome), and its treatment in special circumstances (during pregnancy, in children, or when the portal vein is blocked). They also provide in-depth coverage of the pros and cons of the various therapeutic choices available to the clinician managing patients with complicated portal hypertension.Part I. Historical PerspectivePortal Hypertension: A HistoryAdrian Reuben and Roberto J. GroszmannPart II. Pathobiology and Experimental Progress in Portal HypertensionAnatomy and Vascular Biology of the Cells in the Portal CirculationMassimo Pinzani and Francesco VizzuttiCell and Molecular Mechanisms of Increased Intrahepatic Resistance and Hemodynamic CorrelatesDon C. RockeyMolecular Mechanisms of Systemic Vasodilation and Hyperdynamic Circulatory State of CirrhosisRichard Moreau and Didier LebrecMechanisms of Sodium Retention, Ascites Formation, and Renal Dysfunctionl³-